EFFICIENT HYDROPHOBIC RECOGNITION OF AMINO ACID RESIDUES FOR THE ENHANCEMENT OF ENANTIOSELECTIVITY IN THE HYDROLYSIS OF AMINO ACID ESTERS IN MICELLAR SYSTEMS

Ryuichi UEOKA; Yoko MATSUMOTO; Nobuhiro TAKEMIYA; Yasuji IHARA

doi:10.1248/cpb.37.2263

Ryuichi UEOKA, Yoko MATSUMOTO, Nobuhiro TAKEMIYA, Yasuji IHARA

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Keywords: enantioselectivity, hydrolysis, amino acid ester, peptide catalyst, micellar catalysis, hydrophobic recognition

JOURNAL FREE ACCESS

1989 Volume 37 Issue 8 Pages 2263-2265

DOI https://doi.org/10.1248/cpb.37.2263

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Abstract

An appropriate combination of the sequence of amino acids including a His unit and the hydrophobicity of the side chain in peptide catalysts may effectively enhance the enantioselectivity for the hydrolysis of long-chained enantiomeric substrates.

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