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Chemical and Pharmaceutical Bulletin
Vol. 37 (1989) No. 9 P 2410-2412



A sulfate (GE-3-S) prepared by chlorosulfonic acid treatment of GE-3, a partially acetylated β(1→6) glucan of the lichen Umbilicaria esculenta, inhibited the cytopathic effect of human immunodeficiency virus (HIV) and suppressed the HIV-antigen expresion in Molt-4 (clone 8) cells. GE-3-S also suppressed the giant cell formation of HIV-infected Molt-4 cells, and inhibited HIV-induced plaque formation by 50% at the dose of 19.5μg/ml and completely at 250μg/ml in MT4 cells. GE-3-S had no direct effect on the reverse transcriptase of HIV.

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