Inhibition of Acetylcholinesterase by Diastereomers of 2-Methylamino-1-phynylpropanol and Their Derivatives

Abstract

The anti-acetylcholinesterase activities of the ephedrine diastereomers and their N-methyl derivatives were correlated to the conformation of the molecules in solution. The stereospecificity exhibited by enantiomers of N-methyl-ψ-ephedrinc was attributed to the predominance of one preferred conformation. The possiblity of predicting the absolute configuration of chiral inhibitors from enzyme inhibitions data is discussed.