A Cytotoxic Constituent of Lysimachia japonica THUNB. (Primulaceae) and the Structure-Activity Relationships of Related Compounds

Munehisa ARISAWA; Kazunob OHMURA; Akio KOBAYASHI; Naokata MORITA

doi:10.1248/cpb.37.2431

Munehisa ARISAWA, Kazunob OHMURA, Akio KOBAYASHI, Naokata MORITA

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Keywords: Lysimachia japonica, cytotoxicity, grevillol, 5-alkylresorcinol, structure-activity relationship

JOURNAL FREE ACCESS

1989 Volume 37 Issue 9 Pages 2431-2434

DOI https://doi.org/10.1248/cpb.37.2431

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Abstract

A cytotoxic alkylresorcinol was isolated from Lysimachia japonica THUNB. (Primulaceae) and identified as grevillol (2). t was tested for cytotoxicity against KB, B-16, PC-13, L-5178Y, P-388, and HEp-2 cells in vitro. Synthetic related compounds were also tested for cytotoxicity against the KB cell line, and the structure-activity relationships are discussed.

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