5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines

Shoichiro OZAKI; Takahiko AKIYAMA; Takao MORITA; Masahiro KUMEGAWA; Toshio NAGASE; Nobuaki UEHARA; Akio HOSHI

doi:10.1248/cpb.38.3164

尾崎庄一郎, 秋山隆彦, 森田剛夫, 久米川昌浩, 長瀬敏夫, 上原宣昭, 星昭夫

著者情報

キーワード: 5'-O-acyl-5-fluorouridine, 5-fluorouracil, antitumor activity, 5-fluorouridine, L-1210 leukemia, synthesis

ジャーナルフリー

1990 年 38 巻 11 号 p. 3164-3166

DOI https://doi.org/10.1248/cpb.38.3164

詳細

抄録

Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.

責任著者(Corresponding author)

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