New Antitumor Principles, Casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae)

Hideji ITOKAWA; Nobuo TOTSUKA; Hiroshi MORITA; Koichi TAKEYA; Yoichi IITAKA; Eloir Paulo SCHENKEL; Mario MOTIDOME

doi:10.1248/cpb.38.3384

Hideji ITOKAWA, Nobuo TOTSUKA, Hiroshi MORITA, Koichi TAKEYA, Yoichi IITAKA, Eloir Paulo SCHENKEL, Mario MOTIDOME

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Keywords: casearin, casearins A-F, Casearia sylvestris, Flacourtiaceae, antitumor priciple, clerodane diterpene, sarcoma 180A, V-79 cell, X-ray analysis

JOURNAL FREE ACCESS

1990 Volume 38 Issue 12 Pages 3384-3388

DOI https://doi.org/10.1248/cpb.38.3384

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Abstract

New antitumor clerodane diterpenes, named casearins A-F, have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). These structures have been completely elucidated by two dimensional nuclear magnetic resonance, circular dichroism spectroscopy, X-ray analysis, and chemical evidences.

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