Isolation and Characterization of Hexakis(2, 6-di-O-methyl)cyclomaltohexaose and Octakis(2, 6-di-O-methyl)cyclomalto-octaose : and Their Over-methylated Homologues

Abstract

The methylation of cyclomaltohexaose (α-CD) and cyclomalto-octaose (γ-CD) gave two major components in each case. These methylated compounds were isolated by high-performance liquid chromatography and characterized by carbon-13 unclear magnetic resonance spectroscopy, fast-atom bombardment mass spectrometry, and fragmentation analysis. The two major products from α-CD were hexakis(2, 6-di-O-methyl)cyclomaltohexaose and pentakis(2, 6-di-O-methyl)-mono(2, 3, 6-tri-O-methyl)cyclomaltohexaose and those from γ-CD were octakis(2, 6-di-O methyl)cyclomalto-octaose and heptakis(2, 6-di-O-methyl)-mono(2, 3, 6-tri-O-methyl)cyclomalto-octaose.