Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Cytotoxic Constituents in Pericarps of Mallotus japonicus. IV
Munehisa ARIASAWAAkio FUJITAToshimitsu HAYASHINaokata MORITATohru KIKUCHITasuhiro TEZUKA
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1990 Volume 38 Issue 3 Pages 698-700

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Abstract

Two new phloroglucinol derivatives, isomallotolerin (1) and isomallotochromanol (2), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2, 4-dihydroxy-5-methyl-6-methoxybenxyl)-phlorisobutyrophenone (1) and 6-acetyl-5, 7-dihydroxy-8-(3-acetyl-2, 4-dihydroxy-5-methyl-6-methoxybenxyl)-2, 2-dimethyl-3-hydroxychroman (2) from chemical and spectral data. Isomallotolerin and its acetate were found to be cytotoxic to KB cell line.

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