SYNTHESIS OF SAFRAMYCINS. IV. : SELENIUM OXIDE OXIDATION OF 4-OXO-HEXAHYDRO-1, 5-IMINO-3-BENZAZOCIN-7, 10-DIONE; PROMISING METHOD TO CONSTRUCT SAFRAMYCINS C AND D FROM SAFRAMYCIN B

Naoki SAITO; Yoko OHITA; Akinori KUBO

doi:10.1248/cpb.38.821

齋藤直樹, 大平洋子, 久保陽徳

著者情報

キーワード: saframycin, preparation, hydroxylation, selenium oxide oxidation, stereoselective synthesis, redox reaction

ジャーナルフリー

1990 年 38 巻 3 号 p. 821-823

DOI https://doi.org/10.1248/cpb.38.821

詳細

抄録

9-Methoxy-3, 8, 11-trimethyl-4-oxo-1, 2, 3, 4, 5, 6-hexahydro-1, 5-imino-3-benzazocin-7, 10-dione (13) is oxidized to the corresponding 6-hydroxy compound (14) with selenium oxide. This is a good way to make saframycins C (3) and D (4) from saframycin B (2).

責任著者(Corresponding author)

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