1990 年 38 巻 5 号 p. 1200-1204
The first total synthesis of ochropposinine (1), a Neisosperma and Ochrosia alkaloid, has been accomplished in the form of a racemic modification by means of an initial coupling of the lactim ether (±)-3 with 5 and succeeding steps proceeding through the intermediates (±)-7, (±)-8, (±)-9, (±)-10, and (±)-11. A parallel synthetic route starting with (+)-3 produced the chiral target molecule (-)-1 via the intermediates (+)-7, (+)-8, (+)-9, 10, and (-)-11. As a result, the absolute configuration of ochropposinine has been unequivocally established to be that represented by formula (-)-1.