Studies on Uricosuric Diuretics. I. : Syntheses and Activities of Xanthonyloxyacetic Acids and Dihydrofuroxanthone-2-carboxylic Acids

抄録

A series of substituted xanthonyloxyacetic acids (5 and 6), 1, 2-dihydrofuro[2, 3-c]xanthone-2-carboxylic acids (7) and 2, 3-dihydrofuro[3, 2-b]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.