Kaurane-Type Diterpenes from Adenostemma lavenia O. KUNTZE

Shigeru SHIMIZU; Toshio MIYASE; Kaoru UMEHARA; Akira UENO

doi:10.1248/cpb.38.1308

Shigeru SHIMIZU, Toshio MIYASE, Kaoru UMEHARA, Akira UENO

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Keywords: Adenostemma lavenia, diterpene, kaurane, adenostemmoic acid, adenostemmoside, cytotoxicity, antitumor activity

JOURNAL FREE ACCESS

1990 Volume 38 Issue 5 Pages 1308-1312

DOI https://doi.org/10.1248/cpb.38.1308

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Abstract

Ten 11-oxygenated kauran-19-oic acids, ent-11α, 15α-dihydroxykaur-16-en-19-oic acid, ent-11α-hydroxy-15α-acetoxykaur-16-en-19-oic acid, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acids A-G and their nine glycosides, paniculosides II and III and adenostemmosides A-G were characterized from Adenostemma lavenia O. KUNTZE. ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic acid and adenostemmoic acid B showed cytotoxic activity against L-5178Y cultured cell and prolonged the survival of mice.

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