DESIGN AND SYNTHESIS OF AN OPIOID RECEPTOR PROBE : MODE OF BINDING OF S-ACTIVATED (-)-6β-SULFHYDRYLDIHYDROMORPHINE WITH THE SH GROUP IN THE μ-OPIOID RECEPTOR

Ken KANEMATSU; Ryo NAITO; Yasuyuki SHIMOHIGASHI; Motonori OHNO; Tomio OGASAWARA; Masayasu KURONO; Kunio YAGI

doi:10.1248/cpb.38.1438

兼松顯, 内藤良, 下東康幸, 大野素徳, 小笠原富夫, 黒野昌庸, 八木國夫

著者情報

キーワード: opioid recepter, sulfhydryl group, sulfhydrylmorphine, thiol-disulfide exchange reaction, guinea pig ileum, opioid receptor probe

ジャーナルフリー

1990 年 38 巻 5 号 p. 1438-1440

DOI https://doi.org/10.1248/cpb.38.1438

詳細

抄録

An S-activated sulfhydrylmorphine derivative was synthesized, and its linking to the μ-opioid receptor through a disulfide bond was demonstrated.

責任著者(Corresponding author)

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