The Synthesis and Antilipidperoxidation Activity of 4, 4-Diarylbutylamines and 4, 4-Diarylbutanamides

Seiji MIYANO; Toshio TATSUOKA; Kenji SUZUKI; Kayoko IMAO; Fumio SATOH; Tkafumi ISHIHARA; Ichiro HIROTSU; Tetsuro KIHARA; Mizuho HATTA; Yoshiko HORIKAWA; Kunihiro SUMOTO

doi:10.1248/cpb.38.1570

Seiji MIYANO, Toshio TATSUOKA, Kenji SUZUKI, Kayoko IMAO, Fumio SATOH, Tkafumi ISHIHARA, Ichiro HIROTSU, Tetsuro KIHARA, Mizuho HATTA, Yoshiko HORIKAWA, Kunihiro SUMOTO

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Keywords: 4, 4-diarylbutylamine, 4, 4-diarylbutanamide, synthesis, antilipidperoxidation, lipid peroxidation, cerebral protective agent

JOURNAL FREE ACCESS

1990 Volume 38 Issue 6 Pages 1570-1574

DOI https://doi.org/10.1248/cpb.38.1570

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Abstract

A series of 4, 4-diarylbutylamine and 4, 4-diarylbutanamide derivatives has been synthesized and evaluated for their antilipidperoxidation (ALP) activity and acute toxicity (LD₅₀). Some of them were found to have significant ALP activity.

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