Studies on Cardiotonic Agents. II. : Synthesis of Novel Phthalazine and 1, 2, 3-Benzotriazine Derivatives

Yuji NOMOTO; Hiroyuki OBASE; Haruki TAKAI; Masayuki TERANISHI; Joji NAKAMURA; Kazuhiro KUBO

doi:10.1248/cpb.38.2179

Yuji NOMOTO, Hiroyuki OBASE, Haruki TAKAI, Masayuki TERANISHI, Joji NAKAMURA, Kazuhiro KUBO

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Keywords: positive inotropic activity, cardiotonic agent, structure-activity relationship, phthalazine, 1, 2, 3-benzotriazine, piperidine

JOURNAL FREE ACCESS

1990 Volume 38 Issue 8 Pages 2179-2183

DOI https://doi.org/10.1248/cpb.38.2179

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Abstract

A series of phthalazine and 1, 2, 3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6, 7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

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