The Wittig Reaction of Benzofuran-2, 3-diones

Yasuo TAKEUCHI; Tominari CHOSHI; Hideo TOMOZANE; Hirokazu YOSHIDA; Masatoshi YAMATO

doi:10.1248/cpb.38.2265

Yasuo TAKEUCHI, Tominari CHOSHI, Hideo TOMOZANE, Hirokazu YOSHIDA, Masatoshi YAMATO

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Keywords: α-ketoester, benzofuran-2, 3-dione, Wittig reaction, regioselectivity

JOURNAL FREE ACCESS

1990 Volume 38 Issue 8 Pages 2265-2267

DOI https://doi.org/10.1248/cpb.38.2265

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Abstract

The Wittig reaction of benzofuran-2, 3-diones (2), cyclic α-ketoesters, was examined. The reaction of 2 having an electron-donating substituent on the aromatic ring with a stable ylide afforded not 3-alkylidene-2(3H)-benzofuranones (4) but 2-alkylidene-3(2H)-benzofuranones (1) with high regioselectivity.

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