Studies on Antibacterial Agents. III. : Synthesis and Antibacterial Activities of Substituted 1, 4-Dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids

抄録

A series of substituted 4-oxoquinoline-3-carboxylic acids having a methyl group at the 8-position was prepared and tested for their antibacterial activity. 7-(trans-3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1, 4-dihydro-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid (21) exhibited highly potent antibacterial activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.