Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Antiviral Activities of Glycyrrhizin and Its Modified Compounds against Human Immunodeficiency Virus Type 1 (HIV-1) and Herpes Simplex Virus Type 1 (HSV-1) in Vitro
Kazuhiro HIRABAYASHISusumu IWATAHiroatsu MATSUMOTOTakeo MORIShoji SHIBATAMasanori BABAMasahiko ITOShiro SHIGETAHideki NAKASHIMANaoki YAMAMOTO
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1991 Volume 39 Issue 1 Pages 112-115

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Abstract

Chemically modified compounds of glycyrrhizin have been synthesized and evaluated for their inhibitory effect on the replication of human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). Among them, the 11-deoxo compound having a heteroannular diene structure at the C and D rings proved as active against HIV-1 as glycyrrhizin in MT-4 and MOLT-4 cells. It completely inhibited HIV-1-induced cytopathogenicity in both cell lines at a concentration of 0.16mM. The compound was also effective against HSV-1 with a 50% inhibitory concentration of 0.5μM.

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© The Pharmaceutical Society of Japan
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