Abstract
The title compound showed potent anti-inflammatory and analgesic activities. For the determination of pharmacological activity differences between the optical isomers, we resolved the title compound via diastereomeric separation of the (-)-phenylethyl amide derivatives and followed by amide bond cleavege with N2O4. The absolute configurations of the enantiomers were determined by comparison of the optical rotatory dispersion and circular dichroism spectra with those of known optically active 2-phenylpropionic acids.
