Direct Monitoring by Carbon-13 Nuclear Magnetic Resonance Spectroscopy of the Metabolism and Metabolic Rate of 13C-Labeled Compounds in Vivo

Katsumi IIDA; Osamu HIDOH; Junichi FUKAMI; Masahiro KAJIWARA

doi:10.1248/cpb.39.210

Direct Monitoring by Carbon-13 Nuclear Magnetic Resonance Spectroscopy of the Metabolism and Metabolic Rate of ¹³C-Labeled Compounds in Vivo

Katsumi IIDA, Osamu HIDOH, Junichi FUKAMI, Masahiro KAJIWARA

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Keywords: ^<13>C-NMR in vivo, ^<13>C-glucose, ^<13>C-trehalose, ^<13>C-alanine, ^<13>C-glutamic acid, metabolism, metabolic rate, boric acid

JOURNAL FREE ACCESS

1991 Volume 39 Issue 1 Pages 210-213

DOI https://doi.org/10.1248/cpb.39.210

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Abstract

Carbon-13 nuclear magnetic resonance spectroscopy has been used to observe the transformations of [1-¹³C]-D-glucose to [1, 1'-¹³C₂]-D-trehalose, and [3-¹³C]-L-alanine to [2-¹³C]-L-glutamic acid in the living body of Gryllodes sigillatus. [3-¹³C]-D-Alanine was not metabolized.The metabolic rate of [1-¹³C]-D-glucose was found to be altered by prior injection of boric acid.

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