Synthesis and Salidiuretic Activity of 2, 3-Dihydro-8-(1-pyrrolyl)-1, 2, 4-triazolo[4, 3-a]pyridines and 5, 6-Dihydro-4H-pyrido[2, 3-c]pyrrolo[1, 2-e]-1, 2, 5-triazepines

Abstract

Starting from 2-hydrazino-3-(1-pyrrolyl)pyridine 3 a series of 2, 3-dihydro-8-(1-pyrrolyl-1, 2, 4-triazolo[4, 3-a]-pyridines 49-50 and 5, 6-dihydro-4H-pyrido[2, 3-c]pyrrolo[1, 2-e]-1, 2, 5-triazepines 32-42 were synthesized and tested p.o. in rats for salidiuretic and renal vasodilator activity.