Direct Transformation of O-Glycoside into Glyosyl Bromide with the Combination of Trimethylsilyl Bromide and Zinc Bromide

Kunio HIGASHI; Kiyoshi NAKAYAMA; Emiko SHIOYA; Tsuneo KUSAMA

doi:10.1248/cpb.39.2502

東邦雄, 中山清, 塩谷恵美子, 日馬恒雄

著者情報

キーワード: glycosyl bromide, trimethylsilyl bromide, zinc bromide, glucosamine, glucose, galactose, mannose, O-glycoside

ジャーナルフリー

1991 年 39 巻 10 号 p. 2502-2504

DOI https://doi.org/10.1248/cpb.39.2502

詳細

抄録

A novel direct transformation of O-glycoside into glycosyl bromide by using trimethylsilyl bromide and zinc bromide has been developed. Treatment of various glycosides (3a-5a, 10, 12 and 14) with trimethylsilyl bromide and zinc bromide in dichloromethane afforded the glycosyl bromides (6, 11, 13 and 15) in 53, 85, 94, 47, 41 and 40% yields, respectively.

責任著者(Corresponding author)

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