Biologically Active Constituents of Arnebia euchroma : Structure of Arnebinol, an Ansa-Type Monoterpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis

Xin-Sheng YAO; Yutaka EBIZUKA; Hiroshi NOGUCHI; Fumiyuki KIUCHI; Masaaki SHIBUYA; Yoichi IITAKA; Haruo SETO; Ushio SANKAWA

doi:10.1248/cpb.39.2956

Xin-Sheng YAO, Yutaka EBIZUKA, Hiroshi NOGUCHI, Fumiyuki KIUCHI, Masaaki SHIBUYA, Yoichi IITAKA, Haruo SETO, Ushio SANKAWA

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Keywords: Arnebia euchroma, Boraginaceae, arnebinol, shikonofuran, des-O-methyllasiodiplodin, inhibitor, prostaglandin

JOURNAL FREE ACCESS

1991 Volume 39 Issue 11 Pages 2956-2961

DOI https://doi.org/10.1248/cpb.39.2956

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Abstract

Three phenolic compounds were isolated from the roots of Arnebia euchroma as inhibitors of in vitro prostaglandin biosynthesis. Two known compounds were identified as shikonofurans and des-O-methyllasiodiplodin. The other new compound was named arnebinol and its structure was elucidated as a novel ansa-type monoterpenylbenzenoid derivative.

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