Highly Diastereoselective Reaction of Chiral o-[2-(1, 3-Oxazolidinyl)]benzaldehydes with Alkylmetallic Reagents : Synthesis of Chiral 3-Substituted Phthalides

Hiroshi TAKAHASHI; Takeshi TSUBUKI; Kimio HIGASHIYAMA

doi:10.1248/cpb.39.3136

Hiroshi TAKAHASHI, Takeshi TSUBUKI, Kimio HIGASHIYAMA

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Keywords: asymmetric synthesis, butylmagnesium chloride, (S)-3-butylphthalide, diethylzinc, (S)-3-ethylphthalide, (S)-N-isopropylvalinol, highly diastereoselective reaction, o-[2-(1, 3-Oxazolidinyl)]benzaldehyde, pyridinium chlorochromate

JOURNALS FREE ACCESS

Volume 39 (1991) Issue 12 Pages 3136-3139

DOI https://doi.org/10.1248/cpb.39.3136

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Abstract

Highly diastereoselective reaction of chiral o-[2-(1, 3-Oxazolidinyl)]benzaldehydes (4-6) with alkylmetallic reagents provides a new synthetic method for chiral 3-alkylphthalides.

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