Synthesis of (±)-D-Homocephalotaxine, an Unnatural Analogue of Cephalotaxine

Masahiko OKANO; Naohumi NISHIMURA; Kazumi MARUYAMA; Keigo KOSAKA; Hiroyuki ISHIBASHI; Masazumi IKEDA

doi:10.1248/cpb.39.3163

Masahiko OKANO, Naohumi NISHIMURA, Kazumi MARUYAMA, Keigo KOSAKA, Hiroyuki ISHIBASHI, Masazumi IKEDA

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Keywords: cationic cyclization, Pummerer reaction, sulfoxide, α-chlorosulfide, α-thiocarbocation, cephalotaxine analogue, D-homocephalotaxine

JOURNAL FREE ACCESS

1991 Volume 39 Issue 12 Pages 3163-3167

DOI https://doi.org/10.1248/cpb.39.3163

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Abstract

(±)-D-Homocephalotaxine (2), an Unnatural analogue of cephalotaxine, has been synthesized by a synthetic sequence involving an acid-catalyzed cyclization of the α-sulfinylacetamide 8 as a key step.

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