Prostanoids and Related Compounds. V. Synthesis of 6-Aza-5-oxo-2, 3, 4-trinor-1, 5-inter-m-phenylene Prostacyclin Derivatives

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363

Prostanoids and Related Compounds. V. Synthesis of 6-Aza-5-oxo-2, 3, 4-trinor-1, 5-inter-m-phenylene Prostacyclin Derivatives

Keisuke MIYAJIMA, Masumi TAKEMOTO, Kazuo ACHIWA

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Keywords: 6-aza-5-oxo-2, 3, 4-trinor-1, 5-inter-m-phenylene prostacycline derivative, 1, 3-dipolar cycloaddition, Witting reaction, prostacycline, inhibitory activity, blood platelet aggregation, Prins reaction, Pfitzer-Moffat oxidation

JOURNAL FREE ACCESS

1991 Volume 39 Issue 12 Pages 3175-3179

DOI https://doi.org/10.1248/cpb.39.3175

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Abstract

6-Aza-5-oxo-2, 3, 4-trinor-1, 5-inter-m-phenylene protacyclin derivatives were synthesized by use of 1, 3-dipolar cycloaddition as a key step.

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© The Pharmaceutical Society of Japan

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