Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Biologically Active Constituents of Centipeda minima : Sesquiterpenes of Potential Anti-allergy Activity
呉 金濱秦 堯滔海老塚 豊三川 潮
ジャーナル フリー

1991 年 39 巻 12 号 p. 3272-3275


Ether, methanol and aqueous extracts of Centipeda minima (Compositae) harbs were found to have significant anti-allergy activities in passive cutaneous anaphylaxis (PCA) test. Three flavonoids, two sesquiterpene lactones and an amide were isolated from this plant material as inhibitors to induced histamine release from mast cells. The sesquiterpenes were identified as isobutyroylplenolin and senecioylplenolin by spectral investigations. The flavonoids and sesquiterpenes exhibited significant anti-allergy activity in PCA test with p.o. administration.

© The Pharmaceutical Society of Japan
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