Smiles Rearrangement of 2-(1-Methyl-1H-tetrazol-5-ylthio)acetamides and Their Sulfonyl Derivatives

Katsuyuki ISHII; Minoru HATANAKA; Ikuo UEDA

doi:10.1248/cpb.39.3331

Katsuyuki ISHII, Minoru HATANAKA, Ikuo UEDA

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Keywords: Smiles rearrangement, 2-(1-methyl-1H-tetrazol-5-ylthio)acetamide, 5-amino-1-methyl-1H-tetrazole, 5-mercapto-1-methyl-1H-tetrazole

JOURNAL FREE ACCESS

1991 Volume 39 Issue 12 Pages 3331-3334

DOI https://doi.org/10.1248/cpb.39.3331

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Abstract

The Smiles rearrangement of 2-(1-methyl-1H-tetrazol-5-ylthio)acetamides and their sulfonyl derivatives occurred under basic conditions to yield 5-amino-1-methyl-1H-tetrazole derivatives in excellent yields.

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