Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Glycosylation of the Mitomycins. Syntheses of 7-N-(4-O-Glycosylphenyl)-9a-methoxy-mitosanes
Kimio FURUHATAKanki KOMIYAMAHaruo OGURAToju HATA
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1991 Volume 39 Issue 2 Pages 255-259

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Abstract
Two new derivatives of glycosyl mitomycin C, 7-N-{4-O-(β-D-glucopyranosyl and α-sialosyl)phenyl}-9a-methoxymitosanes, were synthesized, and their structures were elucidated by analysis of the nuclear magnetic resonance spectra. Field desorption mass spectrometry was successfully used for the confirmation of these structures. The cytotoxic, antibacterial, and antitumor activities of 7-N-(4-glycosylphenyl)-9a-methoxymitosanes were also examined.
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© The Pharmaceutical Society of Japan
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