Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Glycosylation of the Mitomycins. Syntheses of 7-N-(4-O-Glycosylphenyl)-9a-methoxy-mitosanes
古畑 公夫小宮山 寛機小倉 治夫秦 藤樹
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1991 年 39 巻 2 号 p. 255-259

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Two new derivatives of glycosyl mitomycin C, 7-N-{4-O-(β-D-glucopyranosyl and α-sialosyl)phenyl}-9a-methoxymitosanes, were synthesized, and their structures were elucidated by analysis of the nuclear magnetic resonance spectra. Field desorption mass spectrometry was successfully used for the confirmation of these structures. The cytotoxic, antibacterial, and antitumor activities of 7-N-(4-glycosylphenyl)-9a-methoxymitosanes were also examined.
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© The Pharmaceutical Society of Japan
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