Marine Sterols. XIX. Polyhydroxysterols of the Soft Corals of the Andaman and Nicobar Coasts. (3). Isolation and Structures of Five New C28 Polyhydroxysterols from Two Sclerophytum sp. Soft Corals

Masaru KOBAYASHI; Fuyuko KANDA; Chunduri Venkata Lakshmana RAO; Saridi Madhava Dileep KUMAR; Desaraju Venkata RAO; Chaganti Bheemasankara RAO

doi:10.1248/cpb.39.297

Marine Sterols. XIX. Polyhydroxysterols of the Soft Corals of the Andaman and Nicobar Coasts. (3). Isolation and Structures of Five New C₂₈ Polyhydroxysterols from Two Sclerophytum sp. Soft Corals

Masaru KOBAYASHI, Fuyuko KANDA, Chunduri Venkata Lakshmana RAO, Saridi Madhava Dileep KUMAR, Desaraju Venkata RAO, Chaganti Bheemasankara RAO

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Keywords: coelenterata, soft coral, Sclerophytum sp., polyhydroxy C₂₈ sterol, 25-deacetyllobosterol, 24-methylcholest-7-ene-3β, 5α, 6β, 25-tetrol 25-monoacetate, 24-methylcholest-22E-ene-3β, 5α, 6β, 25-tetrol, 24-methylcholestane-3β, 5α, 25-triol-6-one 25-monoacetate, 24-methylcholestane-3β, 5α-diol-6-one

JOURNAL FREE ACCESS

1991 Volume 39 Issue 2 Pages 297-300

DOI https://doi.org/10.1248/cpb.39.297

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Abstract

Nine polyhydroxysterols were isolated from the lipid extract of two Sclerophytum sp. soft corals collected in the Andaman and Nicobar Islands. Of these, three compounds (7a, b, and 8) had previously been isolated from the southern Japan soft coral Sarcophyton glaucum. Compound 1 was identified as lobosterol having a novel 6-keto-A/B-cis ring juncture. The structures of the five new compounds were determined as 25-deacetyllobosterol (2), (24S)-24-methylcholest-7-ene-3β, 5α, 6β, 25-tetrol 25-monoacetate (3), (24S)-24-methylcholest-22E-ene-3β, 5α, 6β, 25-tetrol (4), (24S)-24-methylcholestane-3β, 5α, 25-triol-6-one 25-monoacetate (5a) and its C-25 deacetoxy analog (6), from the spectral data and by chemical conversion.

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