Amino Acids and Peptides. XIII. Synthetic Studies on N-Terminal Tripeptide Amide Analogs of Fibrin α-Chain

Koichi KAWASAKI; Toshiki TSUJI; Katsuhiko HIRASE; Masanori MIYANO; Yoshinori IMOTO; Masahiro IWAMOTO

doi:10.1248/cpb.39.584

川崎紘一, 辻俊樹, 平瀬克彦, 宮野雅範, 井本芳則, 岩本雅博

著者情報

キーワード: clotting, water-soluble active ester, peptide synthesis, fibrinogen-thrombin clotting, anticoagulant

ジャーナルフリー

1991 年 39 巻 3 号 p. 584-589

DOI https://doi.org/10.1248/cpb.39.584

詳細

抄録

N-Terminal tripeptide analogs of fibrin α-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting.

責任著者(Corresponding author)

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