Asymmetric Induction Reactions. IV. Palladium-Catalyzed Asymmetric Allylations of Chiral Enamines Bearing Phosphine Groups

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The palladium-catalyzed asymmetric allylations of chiral enamines, derived from (S)-2-(diphenylphosphinomethyl)pyrrolidine, produced optically active α-allyl carbonyl compounds in high optical yields. The phosphino group in the chiral enamines presumably serves as a chiral ligand in these palladium-catalyzed reactions. In the transition states of π-allylpalladium complexes coordinated with the intramolecular phosphine group, the anionic counterparts or allylating reagents are considered to play an important role in controlling of the grade of the enantioselectivity.