Structures and Cytotoxic Activity Relationship of Casearins, New Clerodane Diterpenes from Casearia sylvestris SW.

Hiroshi MORITA; Masahiko NAKAYAMA; Hiroshi KOJIMA; Koichi TAKEYA; Hideji ITOKAWA; Eloir Paulo SCHENKEL; Mario MOTIDOME

doi:10.1248/cpb.39.693

Hiroshi MORITA, Masahiko NAKAYAMA, Hiroshi KOJIMA, Koichi TAKEYA, Hideji ITOKAWA, Eloir Paulo SCHENKEL, Mario MOTIDOME

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Keywords: Casearia sylvestris, Flacourtiaceae, cytotoxicity, clerodane diterpene, casearin, structure-activity relationship

JOURNAL FREE ACCESS

1991 Volume 39 Issue 3 Pages 693-697

DOI https://doi.org/10.1248/cpb.39.693

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Abstract

Casearins G-R, new cytotoxic clerodane diterpenes have been isolated from the leaves of Casearia sylvestris SW. (Flacourtiaceae). Their structures have been elucidated by spectroscopic methods and chemical conversions, and their structure-activity relationships have been discussed.

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