THE INHIBITORY EFFECT OF 3, 3', 4, 5'-TETRAHYDROXYSTILBENE, A CONSTITUENT OF CASSIA GARRETTIANA, ON ANTI-IgE-INDUCED HISTAMINE RELEASE FROM HUMAN BASOPHILS IN VITRO

Yoshihiko INAMORI; Masafumi OGAWA; Hiroshi TSUJIBO; Kimiye BABA; Mitsugi KOZAWA; Hideo NAKAMURA

doi:10.1248/cpb.39.805

Yoshihiko INAMORI, Masafumi OGAWA, Hiroshi TSUJIBO, Kimiye BABA, Mitsugi KOZAWA, Hideo NAKAMURA

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Keywords: 3, 3', 4, 5'-tetrahydroxystilbene, Cassia garrettiana, histamine release, human basophil, disodium cromoglycate, theophylline, oxystilbene derivative

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Volume 39 (1991) Issue 3 Pages 805-807

DOI https://doi.org/10.1248/cpb.39.805

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Abstract

3, 3', 4, 5'-Tetrahydroxystilbene (I__-), a constituent of Cassia garrettiana, strongly inhibited the anti-IgE-induced histamine release from human basophils in vitro at concentrations of 3 to 30 μM. Considering that disodium cromoglycate showed no significant inhibitory activity in this assay method, the strong effect of I__- should be emphasized.

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