SYNTHESIS OF CHIRAL 3-SUBSTITUTED γ-LACTONES AND 9-FURANOSYLADENINE FROM (R)-2-(2, 2-DIETHOXYETHYL)-1, 3-PROPANEDIOL MONOACETATE PREPARED BY LIPASE-CATALYZED REACTION
1991 年 39 巻 3 号 p. 823-825
詳細
1991 年 39 巻 3 号 p. 823-825
A chiral building block, (R)-2-(2, 2-diethoxyethyl)-1, 3-propanediol monoacetate was synthesized in high optical and chemical yields by lipase-catalyzed transesterification. From this compound, we synthesized chiral 3-substituted γ-lactones and a new nucleoside with antiviral activity.
