Diffusion and Reaction of p-Nitroaniline and Succinic Anhydride in Controlled Pore Glass

Abstract

A multi-layered tablet which consisted of controlled pore glass (CPG) and organic compounds was prepared. Addition reactions between succinic anhydride and p-nitroaniline, which were induced separately in the CPG layers of the multi-layered tablet, have been studied. The reaction product, succinyl-p-nitroanilide, was mainly distributed near the p-nitroaniline layer. This can be explained in terms of a higher diffusion rate of succinic anhydride, resulting in its higher vapor pressure. The diffusion rate constant of succinic anhydride in the CPG120 system was evaluated as 6.00×10^-7 cm²/s by fitting the diffusion equation to experimental results.