Nematocidal Principles in "Oakmoss Absolute" and Nematocidal Activity of 2, 4-Dihydroxybenzoates

Ali Mohammad AHAD; Yoshihisa GOTO; Fumiyuki KIUCHI; Yoshisuke TSUDA; Kaoru KONDO; Toshiya SATO

doi:10.1248/cpb.39.1043

Ali Mohammad AHAD, Yoshihisa GOTO, Fumiyuki KIUCHI, Yoshisuke TSUDA, Kaoru KONDO, Toshiya SATO

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Keywords: oakmoss absolute, Evernia prunastri, nematocidal activity, Toxocara canis, dihydroxybenzoate, octyl 2, 4-dihydroxybenzoate, structure-activity relationship

JOURNAL FREE ACCESS

1991 Volume 39 Issue 4 Pages 1043-1046

DOI https://doi.org/10.1248/cpb.39.1043

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Abstract

Nematocidal principles obtained from oakmoss absolute were identified as methyl 2, 4-dihydroxy-3, 6-dimethylbenzoate (2), ethyl 3-formyl-2, 4-dihydroxy-6-methylbenzoate (4), and ethyl 5-chloro-3-formyl-2, 4-dihydroxy-6-methylbenzoate (7). In relation to their structures, the nematocidal activity of 2, 4-dihydroxybenzoates of methyl to tetradecyl was tested and the strongest activity was found in the octyl ester (minimal lethal concentration=13 μM).

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