Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids from Licorice Roots and 4-Arylcoumarins

Ayumu KUSANO; Tamotsu NIKAIDO; Takashi KUGE; Taichi OHMOTO; G.Delle MONACHE; Bruno BOTTA; Maurizio BOTTA; Tamotsu SAITOH

doi:10.1248/cpb.39.930

Ayumu KUSANO, Tamotsu NIKAIDO, Takashi KUGE, Taichi OHMOTO, G.Delle MONACHE, Bruno BOTTA, Maurizio BOTTA, Tamotsu SAITOH

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Keywords: licorice root, cAMP phosphodiesterase, inhibitor, flavonoid, 3-arylcoumarin, 4-arylcoumarin, structure-activity relationship

JOURNAL FREE ACCESS

1991 Volume 39 Issue 4 Pages 930-933

DOI https://doi.org/10.1248/cpb.39.930

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Abstract

Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5, 7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.

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