Complete Structures of Breynins A and B

Hiroaki OHKUMA; Takashi TSUNO; Masataka KONISHI; Takayuki NAITO; Hiroshi KAWAGUCHI

doi:10.1248/cpb.39.942

Hiroaki OHKUMA, Takashi TSUNO, Masataka KONISHI, Takayuki NAITO, Hiroshi KAWAGUCHI

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Keywords: Breynia officinalis, breynin A, breynin B, NMR, 2D-COSY, FAB-MS, six-membered ketal ring, breynogenin triglycoside, hypocholesterolemic activity

JOURNAL FREE ACCESS

1991 Volume 39 Issue 4 Pages 942-944

DOI https://doi.org/10.1248/cpb.39.942

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Abstract

The complete structures of breynins A and B, hypocholesterolemic active compounds isolated from Breynia officinalis HEMSL, have been established by spectroscopic analysis and chemical degradation. Breynin A is 3-O-[α-L-rhamnopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl]breynogenin and breynin B is the 17-hydroxy analog.

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