Prostanoids and Related Compounds. IV. Total Synthesis of Clavulones

Masumi TAKEMOTO; Akira KOSHIDA; Keisuke MIYAZIMA; Kunio SUZUKI; Kazuo ACHIWA

doi:10.1248/cpb.39.1106

Masumi TAKEMOTO, Akira KOSHIDA, Keisuke MIYAZIMA, Kunio SUZUKI, Kazuo ACHIWA

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Keywords: marine prostanoid, clavulone I, clavulone II, clavulone III, clavulone IV, unnatural type dichloro Corey lactone, iodolactonization, alkylation, Wittig reaction

JOURNAL FREE ACCESS

1991 Volume 39 Issue 5 Pages 1106-1111

DOI https://doi.org/10.1248/cpb.39.1106

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Abstract

An efficient and stereoselective synthesis of optically active clavulones has been accomplished by the use of the unnatural type dichloro Corey lactone 1 as a chiral pool.

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