Lipid A and Related Compounds. XXVI. Syntheses of Biologically Active Penta-O-acetyl-N-glycoloylneuraminyl- and Penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic Acid-(α2→6)-D-glucosamine-4-phosphate Analogs of Lipid A

Kiyoshi IKEDA; Kouki KAWAI; Kazuo ACHIWA

doi:10.1248/cpb.39.1305

池田潔, 河合弘毅, 阿知波一雄

著者情報

キーワード: N-acetylneuraminic acid, N-glycoloylneuraminyl-glucosamine-4-phosphate, KDN-glucosamine-4-phosphate, lipid A analog, mitogenic activity

ジャーナルフリー

1991 年 39 巻 5 号 p. 1305-1309

DOI https://doi.org/10.1248/cpb.39.1305

詳細

抄録

The syntheses of novel penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid-(α 2→6)-D-glucosamine-4-phosphate analogues of lipid A containing sialic acid in place of 3-deoxy-D-manno-2-octulosonic acid are described. Preliminary examination of the biological activity revealed that two synthetic disaccharides showed mitogenic activities and weak antitumor activities.

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