The Measurement of cis-Platin and trans-Platin by Graphite Atomic Absorption Spectrophotometry

Abstract

In order to determine a micro amount of cis- and trans-platin (cis- and trans-diamminedichloroplatinum(II)) separately, we have utilized the trans effect of SCN^-.cis-Platin reacted with potassium thiocyanate to give anionic [Pt(SCN)₄]^2- which was extracted into nitroethane as an ion pair with zephiramine. On the other hand, trans-platin gave neutral trans-[Pt(SCN)₂(NH₃)₂] under the same conditions, which was not extracted into nitroethane. Therefore, it is possible to determine cis- and trans-platin, separately, by the solvent extraction method. In the determination of the mixture of cis- and trans-platin (4.00×10^-6 and 2.67×10^-6M, respectively), the recovery of each platinum complex was 94±4 and 101±10% for cis- and trans-platin, respectively.