Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
SYNTHESIS OF BIOLOGICALLY ACTIVE GALACTOSYL AND GLUCOSYL-GLYCEROL DERIVATIVES
Naoki OHTA, Kazuo ACHIWA
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Keywords: lipoteichoic acid, galactosyl-glycerol derivative, glucosyl-glycerol derivative, anti-inflammatory activity, (S)-1-O-acetyl-2-O-benzyl-glycerol
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1991 Volume 39 Issue 5 Pages 1337-1339

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Abstract
Galactosyl and glucosyl-glycerol derivatives which mimic the structure of the lipoteichoic acid of Staphylococcus aureus were synthesized by using a chiral glycerol derivative. Glucosyl-glycerol derivatives (14 and 22) had stronger anti-inflammatory activity than galactosyl-glycerol derivatives (13 and 21).
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© The Pharmaceutical Society of Japan
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