Synthesis of Nucleosides and Related Compounds. XXII. Carbocyclic Analogues of Thymidine and Related compounds from 2-Azabicyclo[2.2.1]hept-5-en-3-ones

Nobuya KATAGIRI; Masahiro NOMURA; Makoto MUTO; Chikara KANEKO

doi:10.1248/cpb.39.1682

Nobuya KATAGIRI, Masahiro NOMURA, Makoto MUTO, Chikara KANEKO

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Keywords: reductive amido bond cleavage; sodium borohydride, carbocyclic nucleoside, 2-azabicyclo[2.2.1]hept-5-en-3-one, epoxidationl, cyclonucleoside, carbocyclic thymidine

JOURNAL FREE ACCESS

1991 Volume 39 Issue 7 Pages 1682-1688

DOI https://doi.org/10.1248/cpb.39.1682

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Abstract

Reductive amido bond cleavage reaction, previously elaborated by our laboratory for the synthesis of carbocyclic ribothymidine from readily available 2-azabicyclo[2.2.1]hept-5-en-3-one, was successfully applied to the synthesis of carbocyclic analogues of thymidine and related compounds.

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