Studies on Antiatherosclerotic Agents. Synthesis and Inhibitory Activities on Platelet Aggregation of 4-Aryl Derivatives of 7-Ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone

Yukuo EGUCHI; Yuko SATO; Satomi SEKIZAKI; Masayuki ISHIKAWA

doi:10.1248/cpb.39.2009

Studies on Antiatherosclerotic Agents. Synthesis and Inhibitory Activities on Platelet Aggregation of 4-Aryl Derivatives of 7-Ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone

江口征夫, 佐藤祐子, 関崎里美, 石川正幸

著者情報

キーワード: synthesis, arylcadmium reagent, coupling reaction, 4-(2-anisyl)-7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone, inhibitory effect, platelet aggregation

ジャーナルフリー

1991 年 39 巻 8 号 p. 2009-2015

DOI https://doi.org/10.1248/cpb.39.2009

詳細

抄録

4-Aryl derivatives of 7-ethoxycarbonyl-6, 8-dimethyl-1(2H)-phthalazinone and related derivatives were newly synthesized in order to test for their inhibitory activities on platelet aggregation. 4-(2-Anisyl) compound and the corresponding 1-chloro derivative demonstrated significant activity.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）