Studies on Hindered Phenols and Analogues. V. Synthesis, Identification, and Antidiabetic Activity of the Glucuronide of CS-045

Takao YOSHIOKA; Yuichi AIZAWA; Takashi FUJITA; Kan-ichi NAKAMURA; Kunihiro SASAHARA; Harumitsu KUWANO; Takeshi KINOSHITA; Hiroyoshi HORIKOSHI

doi:10.1248/cpb.39.2124

Takao YOSHIOKA, Yuichi AIZAWA, Takashi FUJITA, Kan-ichi NAKAMURA, Kunihiro SASAHARA, Harumitsu KUWANO, Takeshi KINOSHITA, Hiroyoshi HORIKOSHI

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Keywords: glucuronide, CS-045, antidiabetic activity, hindered phenol, Macaca fascicularis, KK-mice

JOURNAL FREE ACCESS

1991 Volume 39 Issue 8 Pages 2124-2125

DOI https://doi.org/10.1248/cpb.39.2124

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Abstract

The glucoronide of a new oral antidiabetic agent, (±)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-yl-methoxy)benzyl]thiazolidine-2, 4-dione (CS-045) (1), was synthesized to confirm the stracture of a metabolite in monkeys (Macacafascicularis) and to examine its antidiabetic activity. The glucuronide also had antidiabetic activity in KK-mice.

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