Change of ras-Transformed NRK-Cells Back to Normal Morphology by Mycalamides A and B, Antitumor Agents from a Marine Sponge

Abstract

Mycalamide A and mycalamide B, isolated as antiviral and antitumor agents from a New Zealand sponge of the genus Mycale, converted the morphology of ras-transformed NRK-cells to normal morphology at 10 and 1 ng/ml, respectively. The effect on protein synthesis suggests that these agents converted the morphology by preferentially inhibiting the biosynthesis of p21 protein.