Synthesis and Antitumor Activities of Novel Benzoylphenylurea Derivatives

Hiroshi OKADA; Tohru KOYANAGI; Nobutoshi YAMDA; Takahiro HAGA

doi:10.1248/cpb.39.2308

Hiroshi OKADA, Tohru KOYANAGI, Nobutoshi YAMDA, Takahiro HAGA

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Keywords: benzoylphenylurea, N-(2-nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]urea, N-[4-(5-bromo-2-pyrimidinyloxy)-3-chorophenyl]-N'-(2-nitrobenzoyl)urea, antitumor agent, structure-activity relationship

JOURNAL FREE ACCESS

1991 Volume 39 Issue 9 Pages 2308-2315

DOI https://doi.org/10.1248/cpb.39.2308

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Abstract

Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of subsitituent on each aryl ring.

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