Determination of the Ratio between Optical Isomers, Shikonin and Alkannin by High Performance Liquid Chromatography Analysis

Yoshitaka IKEDA; Naomichi ISHIDA; Chikara FUKAYA; Kazumasa YOKOYAMA; Mamoru TABATA; Hiroshi FUKUI; Gisho HONDA

doi:10.1248/cpb.39.2351

Yoshitaka IKEDA, Naomichi ISHIDA, Chikara FUKAYA, Kazumasa YOKOYAMA, Mamoru TABATA, Hiroshi FUKUI, Gisho HONDA

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Keywords: Boraginaceae, naphthoquinone, shikonin, alkannin, stereoisomer, optical resolution, chiral phase HPLC, Lithospermum erythrorhizon, Alkanna tinctoria

JOURNAL FREE ACCESS

1991 Volume 39 Issue 9 Pages 2351-2352

DOI https://doi.org/10.1248/cpb.39.2351

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Abstract

The optical isomers, shikonin and alkannin, can be separated by chiral phase high performance liquid chromatography. The results of analysis have shown that the commercial standards of "shikonin" or "alkannin" as well as the red pigments extracted from the roots of some Boraginaceous plants contain both optical isomers in various proportions.

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